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AMERICAN MEDICAL ASSOCIATION SCIENTIFIC PAPER OF THE YEAR:

Ultrasound significantly increases the number of small cancers detected in women with dense breasts which would otherwise be missed on a mammogram.

"Mammographic sensitivity for breast cancer declines significantly with increasing breast density and is independently higher in older women with dense breasts. Addition of screening US significantly increases detection of small cancers and depicts significantly more cancers and at smaller size and lower stage than does PE, which detects independently extremely few cancers. Hormonal status has no significant effect on effectiveness of screening independent of breast density."

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FIRST PROSPECTIVE STUDY SHOWING THE LIMITATIONS OF MAMMOGRAPHY IN WOMEN WITH DENSE BREASTS AND THE EFFECTIVENESS OF ULTRASOUND FOR FINDING SMALL CANCERS MISSED BY MAMMOGRAMS

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FIRST LARGE SCALE STUDY OF THE BRCA1 AND BRCA2 MUTATIONS IN ASHKENAZI WOMEN: FROM THE NY BREAST CANCER STUDY GROUP WITH DR. THOMAS KOLB, MD

Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We selected 1008 index cases, regardless of family history of cancer, and carried out molecular analysis across entire families. The lifetime risk of breast cancer among female mutation carriers was 82%,